Background Darunavir (DRV) is a protease inhibitor (PI) that when boosted with ritonavir is effective against both wild-type and PI-resistant HIV. It’s relatively long half-life supports once-daily dosing (QD) in treatment-naïve patients. To treat treatment-experienced patients twice-daily dosing (BID) is preferred.
Purpose To analyse the need for therapeutic drug monitoring (TDM)-guided interventions for darunavir and their results in patients receiving darunavir/ritonavir both in BID and QD modalities.
Materials and Methods A prospective study that included 38 patients was performed: 21 (55.3%) in the BID group and 17 (44.7%) in the QD group. Plasma darunavir levels were determined using an HPLC method and viral loads (VL) were measured. Assessments were performed at inclusion and whenever VL was detectable. Patients with detectable VL load were subjected to intervention (change in dose and/or adherence reinforcement) and another plasma drug determination was scheduled. Interventions were considered successful if VL became undetectable.
Results Abnormal plasma drug levels (outside a 1000–8000 ng/ml range) were found in 13/83 (15.6%) determinations which correspond to 9 patients and in all cases detectable VL were also found. Among measures yielding normal levels the proportion of cases with detectable VL was 49/83 (59%). TDM-guided interventions were performed in 22/38 (58%) patients and were successful in 11 of them (7 BID and 4 QD).
Mean plasma levels in the BID group were greater than in the QD group: 3715 ng/ml (SD:±1679) and 2830 ng/ml (SD:±1030) respectively (p < 0.02). In the BID group cases with undetectable VL had mean plasma levels superior to those of cases with detectable VL: 4524 ng/ml (SD: SD:±1679) versus 3375 (SD:±1679), p < 0.05.
Conclusions TDM-guided interventions could be useful in patients receiving darunavir/ritonavir and experiencing viral failure, especially if the BID dosing modality is used.
No conflict of interest.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.