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CPC-122 Risk Factors in the Incidence of Chemotherapy-Induced Emesis
  1. S Fénix Caballero,
  2. MJ Gándara Ladrón De Guevara,
  3. JF López Vallejo,
  4. MA Blanco Castaño,
  5. C Palomo Palomo,
  6. C Martinez Diaz
  1. Puerto Real Universitary Hospital, Pharmacy Department, Puerto Real, Spain

Abstract

Background Chemotherapy-induced nausea and vomiting (CINV) are the most common side effects after the administration of anticancer drugs. CINV appears in a variable percentage of patients, depending on the cytostatic agent and patients’ risk factors.

Purpose The aim of this study was to evaluate the effect of the risk factors on the incidence of emesis after the administration of the first cycle of chemotherapy.

Materials and Methods A literature search was conducted for articles addressing the risk factors in CINV. Younger age, female sex, history of motion sickness or pregnancy-induced vomiting, radiotherapy and anxiety/depression were included. A history of alcohol intake was considered a protective factor and it was graded as none, mild (1–5 drinks/month), moderate (6–14) or high (>14) consumption. The impact on complete response (CR) of those risk factors for CINV was investigated. CR was defined as no emetic episodes during the overall 5-day study period. Patients’ risk factors were recorded before chemotherapy infusion. All patients received intravenous 5HT3-receptor antagonists before chemotherapy infusion and a two-drug combination (metoclopramide and dexamethasone) on the following four days. Patients kept a diary to report CINV during the 5-day period. Univariate analyses were performed to determine the risk factors significantly associated with emesis after the first cycle of chemotherapy. Risk reduction between CR and non-CR results were calculated. The statistical significance among risk-factor subgroups was also evaluated in order to assess the extent of influence of each one.

Abstract CPC-122 Table 1

Results A total of 30 patients were evaluated. The incidence of emesis is summarised in the table.

Conclusions The younger the patient the less emetic control there was. Although the risk was higher in women, this difference was not significant. None or minor consumption of alcohol had significantly higher risk of emesis than moderate or high. A multivariable analysis may be performed to confirm the relationship between risk factors and CINV.

No conflict of interest.

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