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PP-002 Evaluation of a medical device to improve the security of intraspinal administration of cytotoxic drugs
  1. T Bancourt,
  2. L Baillet,
  3. M Vasseur,
  4. N Simon,
  5. M Longueville,
  6. B Décaudin,
  7. P Odou
  1. Pharmacie CHRUHRU Lille, Nord, Lille Cedex, France

Abstract

Background Intraspinal administration errors are identified in the list of ‘never events’ of the French Health Authority (ANSM). New devices with different connectors incompatible with standard Luer-lock connectors (Univia syringe, Becton-Dickinson) could be used to make the spinal administration of cytotoxic drugs safer. Purpose To perform a feasibility study regarding to the minimum capacity (2 mL).

Materials and methods A comparative study between Univia (U, 2 ml) and Tuberculin (T, BD) syringes was performed. Volumes of water (0.6mL, 0.48mL, 0.15mL, 0.1mL) simulating usual volumes of cytotoxics were measured by an operator and weighed on a precision scale (n = 30). For each volume, accuracy (%) and precision (CV%) were determined. A difference of 10% from the nominal volume was the chosen threshold.

Results For U, the accuracy was 0.2%, 6.5%, 11.2% and 21.8% for 0.6, 0.48, 0.15 and 0.1 mL, respectively. It was 1.2%, 2.0%, 6.1% and 6.1% for T. For U, the precision was 2.4%, 2.3%, 5.9% and 6.2% for 0.6, 0.48, 0.15 and 0.1 mL, respectively whereas it was 1%, 1.0%, 7.3% and 8% for T. Accordingly, the volumes of 0.6 and 0.48 mL may be prepared with U. For both, 0.15 and 0.1 mL, a transfer step with a tuberculin syringe increases both accuracy (3.9%) and precision (3.9%).

Conclusions This study suggests the possibility of using U to compound cytotoxic drugs for intraspinal injection. It remains to evaluate the practical constraints related to the administration.

No conflict of interest.

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