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OHP-015 Current use of aluminium and potassium sulfate in the treatment of haemorrhagic cystitis: a descriptive study
  1. F Cosme Silva1,
  2. P Afonso2,
  3. V Rodrigues1,
  4. MP Ferreira3
  1. 1Hospital de Santa Maria, Farmacotecnia, Lisbon, Portugal
  2. 2Hospital de Santa Maria, Distribuição, Lisbon, Portugal
  3. 3CHLNEPE, Pharmacy, Lisbon, Portugal

Abstract

Background Haemorrhagic cystitis, a bladder inflammation, is considered a medical emergency. It is frequently associated with some drugs, radiotherapy (radic cystitis) of bladder, prostate and cervix cancer and viral infections.(1) Several treatment options are available, which are aluminium and potassium sulfate (alum), aminocaproic acid etc. Particularly, the alum acts as an astringent, leading to protein precipitation and vasoconstriction.(2)

The main objective of this work is to gather relevant information lacking in other published articles.

Purpose Characterisation of patients treated with alum;

Data collection of the number of treatment days, treatment tolerability, adjuvant medication and possible causes for early treatment suspension.

Materials and methods A descriptive, observational and transversal study was carried out in Portugal’s major hospital centre (CHLN). Data was collected between November/2012 and September/2013 from medical prescriptions and interviews. The patients included were all under medically prescribed treatment with alum.

Results Data was collected from nine patients (eight males) with a medium age of 74 years old, and diagnosis of rectal, bladder or prostate cancer. Radic cystitis was the only therapeutic indication. The number of treatment days had a medium value of 2. By doctor’s decision one patient suspended the treatment. In five patients injectable butylscopolamine was administered in order to control bladder contractions, due to the drugs’ administration. Although in one patient was reported pain during the drug administration, it was easily controlled with analgesics.

Conclusions The alum therapy was effective in managing haemorrhagic cystitis, economic and well-tolerated without anaesthesia. There was an expectable variability in the treatment duration since it depends on the evolution of the health status.

Among our hospitals, the alum therapy was established in adults and in oncologic disease nevertheless, some authors refer its use in paediatrics and cystitis of other different etiologic factors.(3)

The determination of serum aluminium might be done to avoid possible toxicity, especially in long treatment.

No conflict of interest.

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