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CP-010 Adherence to long-term medicines in HIV-Infected patients
  1. M Cantudo-Cuenca1,
  2. C Haro Márquez1,
  3. M Cantudo-Cuenca2,
  4. M González-Medina3,
  5. C Gómez-Peña3,
  6. AM Tristancho-Pérez1,
  7. E Calvo-Cidoncha1,
  8. R Morillo Verdugo1
  1. 1Área de Gestión Sanitaria Sur de Sevilla, UGC Farmacia, Sevilla, Spain
  2. 2Hospital San Juan de Dios, Farmacia, Sevilla, Spain
  3. 3Hospital Universitario San Cecilio, UGC Intercentros Interniveles Farmacia Granada, Granada, Spain

Abstract

Background Comorbid chronic conditions have increased among HIV-infected patients. Little work has studied adherence rates for long-term medicines (LTMs).

Purpose To assess adherence to other LTMs (non-antiretroviral therapy) among HIV-infected patients as well as to evaluate its relationship with clinical and therapeutic factors.

Material and methods A cross-sectional study was conducted from May to July 2014 in HIV-infected patients treated with ART and ≥1 LTM. The following variables were collected: sex, age, living situation, employment status, mode of transmission, T-CD4, viral load, CDC classification, type of ART and adherence to other LTM (non-antiretroviral treatment), using the 4-item Morisky Medication Adherence Scale. The chi-squared test was applied to examine the role of the different variables on adherence, using SPSS 20.0.

Results 126 patients were included (80.4% male, mean age 50.4 ± 8.3). Injection drug use was the main mode of transmission (61.9%). The median T-CD4 was 538.5 cells/mm3 (IQR: 341.1–778.2). Most of patients presented T-CD4 ≥ 500 cells/mm3 (56.3%) and undetectable viral load (74.6%). 63.5% of them had AIDS. ART was mainly (36.5%) two nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) with one non-nucleoside reverse transcriptase inhibitor (NNRTI). The percentage of patients adherent to other LTMs (non-antiretroviral therapy) was 46.0%. The variable AIDS exhibited a statistically significant relationship with non-adherence (OR = 2.2; CI [1.1–4.7]; p = 0.041). The most common long-term medicines were sedatives and anxiolytics (42.9%), lipid-lowering drugs (35.7%), antihypertensives (33.3%), gastrointestinals (28.6%), antidepressants (15.1%), antidiabetics (12.7%), analgesics (11.1%), antiasthmatics (9.5%) and cardiovascular drugs (87.9%).

View this table:
Abstract CP-010 Table 1

Conclusion Patients showed a low level of adherence to other LTMs. This study allowed us to attempt to educate HIV-infected patients with suboptimal adherence.

References and/or acknowledgements

  1. Cantudo-Cuenca MR, Jiménez-Galán R, Almeida-Gonzalez CV, et al. Concurrent use of comedications reduces adherence to antiretroviral therapy among HIV-infected patients. J Manag Care Pharm 2014;20(8):844–50

References and/or acknowledgementsNo conflict of interest.

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