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DI-032 Antiretroviral therapy, adherence and quality of life in older hiv-patients with moderate-high cardiovascular risk
  1. E Domingues1,
  2. M Ferrit2,
  3. M Calleja2
  1. 1University Hospital Maria Aparecida Pedrossian, Pharmacy Service, Campo Grande, Brazil
  2. 2University Hospital Virgen de Las Nieves, Pharmacy Service, Granada, Spain

Abstract

Background The availability of more potent drugs, with fewer adverse effects, and new therapeutic strategies, such as simplification and ritonavir-boosted protease inhibitor (PI/r) monotherapy have changed the antiretroviral therapeutic profile of HIV patients.

Purpose To analyse the relationship between antiretroviral therapy (ART), adherence and health-related quality of life (HRQL) in HIV patients older than 50 years, with moderate-high cardiovascular risk (CVR), integrated in a pharmacotherapy follow-up service.

Material and methods Patients on antiretroviral therapy aged over 50, with a CVR ≥ 2 (assessed by the risk score), who signed an informed consent were included. Study variables were obtained through interview, clinical history and pharmacy records. The HRQL was assessed through the MOS-HIV questionnaire1 and the adherence by the SMAQ questionnaire and electronic dispensing record.

Results We included 73 patients, 84% males, median age 54 years (IQR 52–59) who had been diagnosed with HIV for 17 years (IQR 13–20). Median CD4 count 684 cells/mm3 (IQR 469–882) and 93% with undetectable viral load. Adherence according to dispensing records was 93% (89–98) and by SMAQ, 67% were adherent. The most prescribed antiretrovirals were darunavir and tenofovir, 32% of patients had been prescribed an unconventional regimen and 29% PI/r monotherapy, median of three tablets/day (IQR 3–4) and 75% once daily. The domains of HRQL, physical (PHS) and mental (MHS) were significantly higher in: patients over 60 years, patients with more than 10 years of ART and with fewer than 3 tablets/day. Patients not on IP/r had higher scores on all dimensions of HRQL with significant differences in cognitive functioning (p = 0.015).

Conclusion Patients presented antiretroviral therapy in unconventional combinations, more than 90% adherence and undetectable viral load. Antiretroviral treatment strategy could improve the quality of life perceived by the patient.

Reference

  1. Wu AW, Rubin HR, Mathews WC, et al. A health status questionnaire using 30 items from the Medical Outcomes Study: Preliminary validation in persons with early HIV infection. Medical Care 1991;29(8):786–98

ReferenceNo conflict of interest.

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