Background Since 1981, the year of the first case of infection with HIV/AIDS, about 60 million people have been infected with the virus, and some 20 million have died. But since the appearance in 1995 of the so-called highly active antiretroviral therapy, there have been dramatic reductions observed in morbidity and mortality rates.
Material and methods Retrospective observational study in a tertiary hospital. Using the pharmaceutical management software program Savac, the total number of patients receiving EVG/COBI/FTC/TDF from October 2014 to October 2015 (approved use in the hospital) was obtained. The medical record programme Selene provided the following data: age, sex and previous comorbidities. Before initiating a naïve or treatment switch with EVG/COBI/FTC/TDF, the use was approved following the guidelines prepared by the HIV Therapy Group.
Results 28 patients, 19 (68%) men and 9 (32%) women with a mean age of 49 years, were included in the study. 5 naïve patients were identified and the rest were treatment changes. The most common previous treatment schemes were: tenofovir+efavirenz (25%), tenofovir+etravirine (14.3%), tenofovir+darunavir+ritonavir (7%) and lopinavir/ritonavir+tenofovir (7%).
The most common comorbidities inducing treatment switch were hepatitis C virus (23%), dyslipidaemia (21%), hypertension (17%), hypercholesterolaemia (7%), adherence problems (3%) and vitamin D deficiency (1%).
Conclusion According to the document prepared by the regional HIV Therapy Group, its use is preferable in non-compliant patients, prioritising simplicity to prevent selected resistance. In our study, the most common comorbidity that led to its use as treatment was hepatitis C virus. Starting or changing treatment to EVG/COBI/FTC/TDF complied with the document prepared by the HIV Group in all cases.
References and/or Acknowledgements http://www.gesida-seimc.org/contenidos/guiasclinicas/2015/gesida-guiasclinicas-2015-tar.pdf
No conflict of interest.
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