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CP-088 Use of therapeutic plasma exchange-like treatment in our hospital: A review
  1. L Campano Pérez,
  2. CA Crespo Diz
  1. Complejo Hospitalario de Pontevedra, Servicio de Farmacia, Pontevedra, Spain

Abstract

Background Therapeutic plasma exchange (TPE) is a consolidated treatment used in a variety of pathologies. It consists of reducing the plasma concentration of a pathological substance by extracting a volume of the patient’s plasma and restoring it with an equivalent volume of replacement fluid.

Purpose To review the use of the TPE procedure in hospital, patient characteristics, the technique and its results, between January 2014 and September 2015.

Material and methods The TPE procedure was performed using an OPTIA system, sodium citrate with dextrose (anticoagulant) and albumin 5% (replacement fluid). A total of 1–1.5 plasma volumes were exchanged in patients over a period of 2–3 h. All patients were assigned a category and recommendation grade for the TPE based on the criteria of the ASFA. These variables were assessed using the electronic health record system (IANUS): diagnosis, initial treatment, category and recommendation grade, number of TPE treatments administered per patient, number of sessions per TPE and the result.

Results TPE was requested for 8 patients. The disorders treated most were Guillain-Barré and myasthenia gravis. No differences in severity were found. 2 had a category 1-grade 1B recommendation, 1 had a category I-grade 1A, 2 had category II-grade 2C, 1 had category II-grade 1B and the last 2 had category III-grade 2C recommendation. One TPE was administered in 6 patients and 5 in 1. The sessions per TPE oscillated between 5 and 12. The TPE treatment was discontinued in one patient. Overall, the results obtained revealed a temporary or partial improvement in their diseases. Two of the patients included in category II-grade 2C and category I-grade 1A, respectively, did not achieve a quantitative clinical improvement or a subjective response to TPE treatment.

Conclusion

  1. TPE is effective in acute episodes of many disorders resistant to other therapies.

  2. It is necessary to assess TPE recommendation grade in each case.

  3. These criteria are helpful for decision making but are not conclusive in achieving an effective therapeutic use.

References and/or Acknowledgements

  1. Journal of Clinical Apheresis

References and/or AcknowledgementsNo conflict of interest.

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