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Eur J Hosp Pharm doi:10.1136/ejhpharm-2012-000170
  • Short report

Effectiveness of urea in hyponatraemia secondary to heart failure and cirrhosis

  1. J Cabeza-Barrera1
  1. 1Pharmacy Department, UGC Farmacia Granada, Hospital Universitario San Cecilio
  2. 2Pharmacy Department, UGC Farmacia Granada, Hospital Baza
  3. 3Cardiology Department, Hospital Universitario San Cecilio
  1. Correspondence to Dr Susana Belda-Rustarazo, Department of Pharmacy, UGC Farmacia Granada, Hospital Universitario San Cecilio, Avda, Dr Oloriz s/n, Granada 18010, Spain; suebelda{at}hotmail.com
  • Received 26 June 2012
  • Revised 31 October 2012
  • Accepted 1 November 2012
  • Published Online First 5 January 2013

Abstract

We report six cases of hyponatraemia secondary to heart failure and cirrhosis that were corrected after oral administration of crystallised urea (30 g/day in all patients). A marked clinical improvement was observed after <7 days of treatment, with good metabolic control, disappearance of oedema and recovery of plasma sodium levels; the treatment was well tolerated, and there were no major adverse effects. All patients continued to receive furosemide perfusion during their urea treatment, and no fluid restrictions were imposed. Oral urea offers a safe, effective and inexpensive treatment for hyponatraemia associated with heart failure and cirrhosis.

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