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Intrathecal injection of tigecycline in treatment of multidrug-resistant Acinetobacter baumannii meningitis: a case report
  1. Lijiang Wang1,
  2. Jirong Zhang1,
  3. Xiaoqing Yu2,
  4. Jiuzhong Wang1,
  5. Lifeng Cheng1,
  6. Shuzhen Hu1,
  7. Guangliang Han1
  1. 1Department of Neurosurgery, Shengli Oilfield Central Hospital of Binzhou Medical University, Dongying, Shandong, China
  2. 2Department of Pharmacy, Shengli Oilfield Central Hospital of the Binzhou Medical College, Dongying, Shandong, China
  1. Correspondence to
    Lijiang Wang, Department of Neurosurgery, Shengli Oilfield Central Hospital of Binzhou Medical University, Dongying, Shandong 257034, China; wanglijiang200703{at}


The ubiquitous Acinetobacter baumannii is an important and troublesome pathogen of nosocomial infection. Multidrug-resistant A baumannii meningitis is very difficult to treat, usually with high mortality. The disease is generally associated with craniotomy, but rarely with lumbar puncture. However, in our case, a 45-year-old male construction worker suffered multidrug-resistant A baumannii meningitis associated with lumbar puncture. The patient responded poorly to the initial treatment with an intravenous infusion of tigecycline. However, later treatment with an intrathecal injection of tigecycline (concentration 1 mg/mL) at a dose of 10 mg every 12 hours proved to be highly efficacious. Thus, intrathecal injection of tigecycline should be seriously considered as a treatment for multidrug-resistant A baumannii meningitis.

  • tigecycline
  • injection
  • multidrug-resistant
  • acinetobacter baumannii
  • meningitis

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