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Analysis of self-reported adverse reactions to efavirenz and drug interactions in a population with HIV in Mexico
  1. María Fernanda Martínez-Salazar1,
  2. Jesús Oaxaca-Navarro2,
  3. Alfonso Leija-Salas3,
  4. Sara García-Jiménez3,
  5. Miguel Angel Sánchez-Alemán4,
  6. Myrna Déciga-Campos1
  1. 1 Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México
  2. 2 CAPASITS Cuernavaca, Servicios de Salud del Estado de Morelos, Cuernavaca, Morelos, México
  3. 3 Facultad de Farmacia, Universidad Autónoma del Estado de Morelos Cuernavaca, Morelos, México
  4. 4 Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México
  1. Correspondence to María Fernanda Martínez-Salazar, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, CP 11350 Ciudad de México, México; fernandamartinez{at}uaem.mx

Abstract

Objective To analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico.

Materials and methods Cross-sectional study conducted in a clinic specialising in HIV ‘CAPASITS-Cuernavaca’ in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student's t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ2 test was used. All tests used a significance level of 0.05.

Results A total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people.

Conclusions The results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.

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