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Letter
Pemetrexed stability: additional information about microparticles
  1. Elise D’Huart,
  2. Jean Vigneron,
  3. Sophie Morice,
  4. Pauline Lider,
  5. Béatrice Demoré
  1. Department of Pharmacy, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, France
  1. Correspondence to Elise D’Huart, Department of Pharmacy, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, 545411, France; dhuartelise{at}gmail.com

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Introduction

The chemical stability of pemetrexed solutions diluted in 0.9% sodium chloride (0.9% NaCl) and 5% dextrose (D5%) in PVC infusion bags at 2–8°C was determined by High Performance Liquid Chromatography (HPLC) for 1 month by Zhang and Trissel1 and Rondelot et al.2 However, subvisual examination shows an increase in turbidimetry and in the number of microparticulates after storage at 2–8°C. The hypothesis of an interaction with PVC was advanced and the use of an inline filter was advised.1 The discrepancy between the nephelometric evaluation and HPLC analysis could be due to the requirement to dilute the samples with the HPLC method. Dilution before analysis increases the solubility, a microprecipitate can be dissolved, …

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