RT Journal Article SR Electronic T1 Analysis of self-reported adverse reactions to efavirenz and drug interactions in a population with HIV in Mexico JF European Journal of Hospital Pharmacy JO Eur J Hosp Pharm FD British Medical Journal Publishing Group SP ejhpharm-2016-001106 DO 10.1136/ejhpharm-2016-001106 A1 María Fernanda Martínez-Salazar A1 Jesús Oaxaca-Navarro A1 Alfonso Leija-Salas A1 Sara García-Jiménez A1 Miguel Angel Sánchez-Alemán A1 Myrna Déciga-Campos YR 2017 UL http://ejhp.bmj.com/content/early/2017/03/16/ejhpharm-2016-001106.abstract AB Objective To analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico.Materials and methods Cross-sectional study conducted in a clinic specialising in HIV ‘CAPASITS-Cuernavaca’ in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student's t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ2 test was used. All tests used a significance level of 0.05.Results A total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people.Conclusions The results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.