TY - JOUR T1 - Progression of systemic lupus erythematosus associated with propofol administration: a case report JF - European Journal of Hospital Pharmacy JO - Eur J Hosp Pharm DO - 10.1136/ejhpharm-2017-001255 SP - ejhpharm-2017-001255 AU - Yang Yu AU - Huan Gui AU - Kai Xiong AU - Xiangdong Fang AU - Jiake He Y1 - 2017/07/13 UR - http://ejhp.bmj.com/content/early/2017/07/13/ejhpharm-2017-001255.abstract N2 - Propofol is a sedative-hypnotic agent used as a general anaesthetic with a good safety profile. However, the potential risk for patients with systemic lupuserythematosus (SLE) receiving propofol remains unclear. We report the case of a patient who received an intravenous infusion of propofol for painless gastroscopy which exacerbated acute SLE despite no history of allergies. The adverse effect might be because propofol increased T helper cells and trigged the induction of B cell differentiation and plasmablast formation, which further promoted the secretion of auto-antibodies. This case shows that propofol can exacerbate SLE symptoms in some patients and highlights the importance of identifying potential immune-related factors before propofol administration, especially in patients with autoimmune diseases. It is important to be aware of and differentiate this uncommon and non-specific SLE manifestation from a myriad of disorders presenting with a primary digestive disorder in the outpatient clinic. ER -