RT Journal Article
SR Electronic
T1 Validation of the LESS-CHRON criteria: reliability study of a tool for deprescribing in patients with multimorbidity
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP ejhpharm-2017-001476
DO 10.1136/ejhpharm-2017-001476
A1 Aitana Rodríguez-Pérez
A1 Eva Rocío Alfaro-Lara
A1 María Isabel Sierra-Torres
A1 Ángela Villalba-Moreno
A1 María Dolores Nieto-Martin
A1 Mercedes Galván-Banqueri
A1 Bernardo Santos-Ramos
YR 2018
UL http://ejhp.bmj.com/content/early/2018/05/30/ejhpharm-2017-001476.abstract
AB Objective The ‘LESS-CHRON criteria’ (List of Evidence-Based Deprescribing for Chronic Patients criteria) is a newly created tool with 27 criteria to guide deprescribing. It was developed using a Delphi methodology. Each criterion consists of drugs and their indications, conditions under which deprescribing would be considered, a health variable to be monitored after deprescribing and a follow-up period. The aim of our study was to evaluate the reliability of the LESS-CHRON criteria in a population of patients with multimorbidity to determine the possible usefulness of this tool in clinical practice.Methods We selected chronic patients with multimorbidity from an internal medicine unit who were older than 80 years old and were alive at the time of the study. To determine interobserver reliability, each professional (internist or hospital pharmacy specialist) applied the questionnaire under the same conditions and with the same resources. To determine intraobserver reliability, each health professional applied the tool at baseline and 2 months later. We measured interobserver and intraobserver reliability using the kappa coefficient. The proportion of overall agreement was also determined.Results We obtained a moderate overall kappa (ĸ=0.46, 95% CI 0.36 to 0.55) for interobserver reliability, and good (ĸ=0.65, 95% CI 0.57 to 0.78) and moderate (ĸ=0.59, 95% CI 0.49 to 0.74) values for intraobserver reliability for the internist and pharmacist, respectively. The proportion of overall agreement was very high: 92% (range: 62%–100%) for the interobserver, and 94% (80%–100%) and 93% (63%–100%) for the internist and pharmacist, respectively.Conclusions The LESS-CHRON criteria shows early promise as a reliable method to help guide deprescribing in patients with multimorbidity. Further, more complete testing with a larger sample of prescribers is needed.