| Anti-nausea regimen | Cost / patient | Patients with CR | Cost of treatment for all patients | ||
|---|---|---|---|---|---|
| + 2 | APR + DEX + LOR | APR (125 mg day 1; 80 mg days 2-3) + DEX (4 mg days 2-3 BID; 2 mg days 4-5 BID) + LOR (0.5-1 mg BID days 2-3) | 58.53 € | 11 (4.3%) | 643.83 € |
| + 1 | DEX + MET + LOR | DEX (8 mg days 2-3 BID; 4 mg days 4-5 BID) + MET (20 mg TID days 2-5) + LOR (0.5-1 mg BID days 2-3) | 4.18 € | 10 (3.9%) | 41.80 € |
| Standard | DEX + MET | DEX (8 mg days 2–3 BID; 4 mg days 4–5 BID) + MET (20 mg TID days 2–5) | 4.13 € | 89 (34.8%) | 367.57 € |
| -1 | DEX + MET if required | DEX (8 mg days 2–3 BID; 4 mg days 4–5 BID) + MET (20 mg TID days 2–5 only if nausea/vomiting) | 4.13 € | 65 (25.4%) | 268.45 € |
| -2 | DEX alone | DEX (8 mg days 2–3 BID; 4 mg days 4–5 BID) | 3.20 € | 39 (15.2%) | 124.80 € |
| -3 low-dose DEX | DEX (4 mg days 2–3 BID; 2 mg days 4–5 BID) | 2.46 € | 42 (16.4%) | 103.32 € | |
APR, aprepitant; DEX, dexamethasone; LOR, lorazepam; MET, metoclopramide.