Table 3

Results of the high performance liquid chromatography determinations of drug concentrations in the remifentanil–human insulin–midazolam combination.

	% of expected concentration
	Dynamic simulation					Test tube
Active drug	Calculated flow rate	2 h	4 h	6 h	24 h	0 h	24 h	Relative difference (%)
Remifentanil	1 ml/h^*	96.0	95.7	95.3	98.4	101.3	99.3	−2.04
Midazolam	1 ml/h^*	109.8	102.0	94.1	91.2	104.8	105.3	0.48
Insulin	1 ml/h^*	–	–	–	–	107.0	105.1	−1.77
Maintenance infusion	1 ml/h^*
Remifentanil	1 ml/h^*	95.3	94.4	95.4		91.8	90.3	−1.65
Midazolam	1 ml/h^*	102.6	107.7	101.8		94.3	94.7	0.42
Insulin	4 ml/h^*	–	–	–		98.1	100.1	2.02
Maintenance infusion	1 ml/h^*
Remifentanil	1 ml/h^*	98.0	100.8	102.8		110.2	109.5	−0.66
Midazolam	4 ml/h^*	104.5	100.5	97.6		100.5	102.0	1.49
Insulin	1 ml/h^*	–	–	–		101.4	102.1	0.69
Maintenance infusion	1 ml/h^*
Remifentanil	1.06 ml/h	100.3	103.3	103.9		94.2	95.0	0.85
Midazolam	4.16 ml/h	105.7	102.4	102.2		97.0	96.9	−0.10
Insulin	4.20 ml/h	–	–	–		104.8	103.9	−0.86
Maintenance infusion	1.00 ml/h
Remifentanil	4.28 ml/h	107.1	106.8	105.5		108.3	109.0	0.64
Midazolam	1.15 ml/h	109.7	108.1	108.9		101.2	100.3	−0.89
Insulin	1.14 ml/h	–	–	–		102.3	101.5	−0.79
Maintenance infusion	1.26 ml/h
Remifentanil	3.86 ml/h	99.4	100.9	102.7		97.6	97.9	0.31
Midazolam	1.08 ml/h	108.8	106.7	106.7		93.5	92.5	−1.08
Insulin	4.27 ml/h	–	–	–		104.2	103.3	−0.87
Maintenance infusion	1.19 ml/h
Remifentanil	4.14 ml/h	104.8	105.2	105.9		98.2	97.8	−0.40
Midazolam	4.09 ml/h	105.6	105.8	103.2		91.3	90.4	−0.98
Insulin	1.08 ml/h	–	–	–		104.2	105.2	0.96
Maintenance infusion	1.12 ml/h

↵* The syringe not having been weighed, the flow rate could not be calculated.