Table 1

Clinical significance according to the motive for the intervention

Type of interventionClinical significanceN%
Economic savingNo error00.0
Documented drug allergySerious12.5
Clarification of the physician's order/request for informationNo error512.5
Therapeutic duplicationSignificant12.5
Dose error: resulting in potentially toxic concentrationsSerious317.5*
Dose error: 1.5–10 times higher than normal (if drug had a normal therapeutic range)Significant1
Dose error: 1.5–4 times higher than normal (if drug had a narrow therapeutic range)Significant0
Dose error: 10 times higher than normal (if drug had a narrow therapeutic range)Potentially lethal1
Dose error: 10 times higher than normal (if drug had a normal therapeutic range)Serious1
Dose error: 4–10 times higher than normal (if drug had a narrow therapeutic range)Serious1
Dose error: very low in non-potentially life-saving drugsSignificant37.5
Dose error: very low in potentially life-saving drugsPotentially lethal0
Repackaging error/physician's order led to error of dispensingSerious00.0
Pharmaceutical form inappropriate or not availableMinor25.0
Illegible, ambiguous or incomprehensible abbreviationsMinor00.0
Non-adherence to hospital policyMinor00.0
Incomplete information in the physician's orderMinor12.5
Interaction: clinically significant, requiring follow-upSignificant25.0
Interaction: combination contraindicatedPotentially lethal0
Inappropriate dosage intervalSignificant615.0
Drug not supplied by companyNo error00.0
Drug not indicated (indication not studied or with no evidence of use)Serious00.0
Drug not included in guidelinesMinor00.0
Omission of a drug from the physician's order (indication not treated)Significant37.5
Omission of a preventive measure to avoid adverse reactionsSignificant12.5
Omission of testing in drugs with possible hypersensitivitySerious00.0
Adverse reaction with a threat to the life of the patientPotentially lethal12.5
Adverse reaction related to precautions or contraindicationsSerious25.0
Sequential therapyMinor00.0
Route of administration that could lead to mild toxicityMinor12.5
Route of administration that could lead to severe toxicitySerious25.0
Information on the administration of parenteral/oral drugsSignificant25.0
  • *Interventions related to errors involving drug overdose.