Variability of the area under the curve (AUC)*
| Formulation | Trade name | Range (%) | Mean (%) | Reference | Score (%) |
|---|---|---|---|---|---|
| Sublingual | Abstral | 27–35 32 | 32 | 31 32 | 68 |
| Sublingual | Recivit | 34 | 34 | Data on file | 66 |
| Oromucosal | Actiq | 33 56–97 30–62 37 | 48 | 33 34 35 36 | 52 |
| Buccal tablet | Effentora | 40–52 35 52 35 46 47–52 34 47 42 27 27 25 | 40 | 37 38 39 40 18 41 42 43 28 24 25 26 | 60 |
| Buccal tablet | Breakyl | 20–32 33 40 | 33 | 44 36 45 | 67 |
| Nasal spray | Instanyl | 26 40 29–45 | 35 | 46 47 48 | 65 |
| Nasal spray | PecFent | 8–49 58 | 40 | 49 50 | 60 |
*AUC, variability (standardised to 400 µg).