Table 1

(Data from Lundgren with permission)

With clear benefitUnclear benefitDo not benefit
Symptom reliefContinue but possibly adjust the doseEvaluate, for example, by treatment interruptionTerminate direct/phase out.
Try new treatment.
PreventiveContinue but possibly adjust the doseSeek better optionsTerminate direct/phase out.
Consider other treatment.
Doubtful or not approved treatmentConsider other treatment or continue if strong reason existSeek better options with approved indicationTerminate direct/phase out.
Try possibly new treatment.