Table 1

(Data from Lundgren with permission)

	With clear benefit	Unclear benefit	Do not benefit
Symptom relief	Continue but possibly adjust the dose	Evaluate, for example, by treatment interruption	Terminate direct/phase out. Try new treatment.
Preventive	Continue but possibly adjust the dose	Seek better options	Terminate direct/phase out. Consider other treatment.
Doubtful or not approved treatment	Consider other treatment or continue if strong reason exist	Seek better options with approved indication	Terminate direct/phase out. Try possibly new treatment.