With clear benefit | Unclear benefit | Do not benefit | |
Symptom relief | Continue but possibly adjust the dose | Evaluate, for example, by treatment interruption | Terminate direct/phase out. Try new treatment. |
Preventive | Continue but possibly adjust the dose | Seek better options | Terminate direct/phase out. Consider other treatment. |
Doubtful or not approved treatment | Consider other treatment or continue if strong reason exist | Seek better options with approved indication | Terminate direct/phase out. Try possibly new treatment. |