Adverse events in the discretionary and mandatory groups
| Grade (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Discretionary (n=89) | Mandatory (n=74) | |||||||||
| Adverse events | 1 | 2 | 3 | Any | ≥2 | 1 | 2 | 3 | Any | ≥2 |
| Skin rash | 9.0 | 12.4 | 1.1 | 22.5 | 13.5 | 14.9 | 2.7 | 0 | 17.6 | 2.7* |
| Fatigue | 32.6 | 5.6 | 0 | 38.2 | 5.6 | 35.1 | 9.5 | 0 | 44.6 | 9.5 |
| Nausea | 23.6 | 15.7 | 0 | 39.3 | 15.7 | 28.4 | 12.1 | 0 | 40.5 | 12.1 |
| Appetite loss | 34.8 | 15.7 | 0 | 50.5 | 15.7 | 31.1 | 13.5 | 0 | 44.6 | 13.5 |
*p=0.0003.