Elsevier

The Journal of Pediatrics

Volume 72, Issue 1, January 1968, Pages 119-120
The Journal of Pediatrics

Editorial comment: Therapeutic orphans

https://doi.org/10.1016/S0022-3476(68)80414-7Get rights and content

References (3)

  • ShirkeyH.C.
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    Paediatric drug research has long been predominantly governed by the extrapolation of knowledge gained in adults without actually testing medicines in children. The understanding of age-dependent physiological changes and their impact on drug disposition has long been obscure and systematic research activities only emerged in recent years (Hirschfeld and Saint-Raymond, 2011; Richey et al., 2013; Miller and Letendre, 1999; Turner et al., 2014; Shirkey, 1968). The vulnerability of the paediatric population within clinical research, practical difficulties in recruiting paediatric patients, decreased commercial interest, increased cost, and a greater risk of liability, remained pivotal arguments to neglect paediatric centred research and drug development.

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