Editorial comment: Therapeutic orphans
References (3)
Cited by (329)
Inclusion of Children in Clinical Research: The Role of Advocacy and a Personal Journey
2023, Pediatric Clinics of North AmericaPractical and operational considerations related to paediatric oral drug formulation: An industry survey
2022, International Journal of PharmaceuticsCitation Excerpt :Paediatric drug research has long been predominantly governed by the extrapolation of knowledge gained in adults without actually testing medicines in children. The understanding of age-dependent physiological changes and their impact on drug disposition has long been obscure and systematic research activities only emerged in recent years (Hirschfeld and Saint-Raymond, 2011; Richey et al., 2013; Miller and Letendre, 1999; Turner et al., 2014; Shirkey, 1968). The vulnerability of the paediatric population within clinical research, practical difficulties in recruiting paediatric patients, decreased commercial interest, increased cost, and a greater risk of liability, remained pivotal arguments to neglect paediatric centred research and drug development.
Will artificial intelligence widen the therapeutic gap between children and adults?
2024, Pediatric Investigation