Pharmacokinetic properties of fentanyl effervescent buccal tablets: A phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 μg in healthy adult volunteers*
References (14)
- et al.
Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain
J Pain Symptom Manage
(2005) - et al.
Break through cancer pain: A randomized trial comparing oral transmucosal fentanyl citrate (OTFC) and morphine sulfate immediate release (MSIR)
Pain
(2001) Transdermal fentanyl: Suggested recommendations for clinical use
J Pain Symptom Manage
(1992)Fentanyl
J Pain Symptom Manage
(2005)- et al.
Consensus panel recommendations for the assessment and management of breakthrough pain: Pam 2: Management
Pharm Ther.
(2005) - et al.
Alternatives to oral opioids for cancerpain
Oncology (Willismn Park)
(1999)et al.Alternatives to oral opioids for cancerpain
Oncology (Willismn Park)
(1999) The role of oral transmucosal fentanyl citrate in the management of breakthrough cancer pain
Int J Palliat Nurs
(2002)
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Single-Dose Pharmacokinetics of Fentanyl Sublingual Spray and Oral Transmucosal Fentanyl Citrate in Healthy Volunteers: A Randomized Crossover Study
2013, Clinical TherapeuticsCitation Excerpt :All the reported adverse events were mild, and none occurred in >2 participants in any treatment period. There were no major differences in adverse event profiles between treatments, which were comparable with those previously reported in healthy volunteers receiving transmucosal fentanyl preparations accompanied by naltrexone.27–30 This study found that FSS provided faster drug absorption and had greater bioavailability than OTFC.
Fentanyl (transmucosal)
2012, Journal of Pain and Symptom ManagementCitation Excerpt :About two-thirds of any swallowed fentanyl will be eliminated by intestinal or hepatic first-pass metabolism. Nonetheless, significant amounts of swallowed fentanyl are absorbed, e.g., about 25%, 20% and 15% of the systemically available Actiq®, Onsolis® and Fentora®, respectively, is via GI absorption.6,8,15 The effects of the GI absorption on the plasma concentration of fentanyl include producing a ‘double peak,’ maintaining high levels for longer (e.g., >2 h) and contributing to the wide range in Tmax.5
Pharmacokinetics of Fentanyl Buccal Tablet: A Pooled Analysis and Review
2012, Pain PracticeCitation Excerpt :Thus, this highlights the finding that, with FBT, Cmax does not need to be reached for onset of efficacy. The pharmacokinetics of FBT has been assessed in numerous studies to date.18 19 22 23 24 25 26 27 29 This article presents a consolidated analysis of the pharmacokinetic profile of FBT based on pooled data from nine pharmacokinetic studies.
Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin b<inf>2</inf> on the Pharmacokinetics of Saikosaponin a in Rats
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This work was previously published in abstract form: Darwish M, Messina J, Tempero K Relative bioavailability and dose proportionality of a novel effervescent form of fentanyl in healthy volunteers. Anesthesiology. 2005;103:A790. Available at: http://www.asabstracts.com/strands/asaabstracts/abstract.htm; jsessionid=0E021F123BAA6313802B30E8044FB145?year=2005&index=6&absnum=1066.