Elsevier

Psychosomatics

Volume 46, Issue 5, September–October 2005, Pages 464-494
Psychosomatics

Med-Psych Drug-Drug Interactions Update
An Overview of Psychotropic Drug-Drug Interactions

https://doi.org/10.1176/appi.psy.46.5.464Get rights and content

The psychotropic drug-drug interactions most likely to be relevant to psychiatrists’ practices are examined. The metabolism and the enzymatic and P-glycoprotein inhibition/induction profiles of all antidepressants, antipsychotics, and mood stabilizers are described; all clinically meaningful drug-drug interactions between agents in these psychotropic classes, as well as with frequently encountered nonpsychotropic agents, are detailed; and information on the pharmacokinetic/pharmacodynamic results, mechanisms, and clinical consequences of these interactions is presented. Although the range of drug-drug interactions involving psychotropic agents is large, it is a finite and manageable subset of the much larger domain of all possible drug-drug interactions. Sophisticated computer programs will ultimately provide the best means of avoiding drug-drug interactions. Until these programs are developed, the best defense against drug-drug interactions is awareness and focused attention to this issue.

Cited by (0)

1

Dr. Sandson is the author of Drug Interactions Case Book: The Cytochrome P450 System and Beyond (American Psychiatric Publishing Inc., 2003).

2

Drs. Armstrong and Cozza are co-authors, along with Dr. Jessica R. Oesterheld, of the Concise Guide to Drug Interaction Principles for Medical Practice: Cytochrome P450s, UGTs, P-Glycoproteins, 2nd edition (American Psychiatric Publishing, Inc., 2003).

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