Compatibility of ketamine and morphine injections

Pain. 1998 Apr;75(2-3):389-90. doi: 10.1016/s0304-3959(97)00176-0.

Abstract

The compatibility of ketamine and morphine mixture was studied. In addition, pH adjustment to minimise local tissue irritation led to no change in stability of the mixture up to pH 5.9. It appears that ketamine and morphine mixtures are stable over a 24 h period.

MeSH terms

  • Drug Combinations
  • Drug Interactions
  • Drug Stability
  • Feasibility Studies
  • Humans
  • Hydrogen-Ion Concentration
  • Injections
  • Ketamine / chemistry
  • Ketamine / pharmacology*
  • Ketamine / radiation effects
  • Light
  • Morphine / chemistry
  • Morphine / pharmacology*
  • Morphine / radiation effects
  • Sodium Bicarbonate / pharmacology
  • Time Factors

Substances

  • Drug Combinations
  • Ketamine
  • Morphine
  • Sodium Bicarbonate