Regular physical activity using large muscle groups, such as walking, running, or swimming,
produces cardiovascular adaptations that increase exercise capacity, endurance, and …

Executive summary The Lancet Countdown is an international collaboration that
independently monitors the health consequences of a changing climate. Publishing …

Background The use of telehealth steadily increases as it has become a viable modality to
patient care. Early adopters attempt to use telehealth to deliver high-quality care. Patient …

Chronic activation of the immune system is a hallmark of progressive HIV infection and
better predicts disease outcome than plasma viral load, yet its etiology remains obscure …

Background The optimal time for the initiation of antiretroviral therapy for asymptomatic
patients with human immunodeficiency virus (HIV) infection is uncertain. Methods We …

Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-
CoV-2 infection is crucial for understanding immune protection and identifying targets for …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

Human longevity is a complex phenotype with a significant familial component, yet little is
known about its genetic antecedents. Increasing evidence from animal models suggests that …

Type 2 diabetes may be a risk factor for dementia, but the associated pathological
mechanisms remains unclear. We evaluated the association of diabetes alone or combined …

Background To date, 750 000 patients with COVID-19 worldwide have required mechanical
ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We …