Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in
patients with Alzheimer's disease (AD). Although a connection between AD and diabetes …

Western societies experienced drastic changes in eating habits during the past century. The
modern nutritional profile, typically rich in saturated fats and refined sugars, is recognized as …

The response to DNA damage is critical for cellular homeostasis, tumor suppression,
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …

The global prevalence of obesity has been steadily increasing. Although pharmacotherapy
and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may …

Introduction: Chikungunya (CHIK) is a tropical arbovirus, transmitted by the female mosquito
Aedes aegypti and Aedes albopictus. In Brazil, there have been cases reported since 2014 …

Brain accumulation of soluble amyloid-β oligomers (AβOs) has been implicated in synapse
failure and cognitive impairment in Alzheimer's disease (AD). However, whether and how …

Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour
types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro …

Primates are remarkably adept at ranking each other within social hierarchies, a capacity
that is critical to successful group living. Surprisingly little, however, is understood about the …

Alzheimer9s disease (AD) is characterized by progressive cognitive decline, increasingly
attributed to neuronal dysfunction induced by amyloid-β oligomers (AβOs). Although the …

Considerable clinical and epidemiological evidence links Alzheimer's disease (AD) and
depression. However, the molecular mechanisms underlying this connection are largely …