Cancer cell dissemination during very early stages of breast cancer proceeds through poorly
understood mechanisms. Here we show, in a mouse model of HER2+ breast cancer, that a …

Natural killer (NK) cells are commonly reduced in human tumors, enabling many to evade
surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found …

Myeloid cells are known to suppress antitumour immunity. However, the molecular drivers of
immunosuppressive myeloid cell states are not well defined. Here we used single-cell RNA …

El aumento de la expectativa de vida de la población, unido al decrecimiento de la
natalidad en los países desarrollados y algunos en vías en desarrollo, son responsables …

Background: Fluorescence polarization immunoassay (FPIA) has probably been the most
widely used technique for the determination of methotrexate (MTX) concentrations in clinical …

Results Liver showed the highest age-dependent changes in mRNA levels of the different
components of Q-synthesis complex, affecting the extent of the variation as well as the …

Macrophages (MΦ) form a highly heterogenous compartment within tumor lesions. Using
lineage tracing, we recently established that advanced NSCLC lesions in both mice and …

Las parasitosis intestinales es un problema de salud en zonas rurales de la República
Bolivariana de Venezuela y es la población infantil la mayormente afectada. Los objetivos …

Background The use of intrathecal (IT) methotrexate (MTX) in combination with systemic
high dose MTX (HDMTX) is an established procedure for CNS prophylaxis in patients with …

Background Intrathecal administration of methotrexate (MTX) in the treatment of different
neoplastic diseases to prevent relapses in the CNS and the need to keep MTX …