Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …

Given the substantial morbidity and mortality associated with type 2 diabetes, it is important
that public health seek ways to delay or prevent the onset of this condition. Risk factors for …

Vaginal ring devices capable of providing sustained/controlled release of incorporated
actives are already marketed for steroidal contraception and estrogen replacement therapy …

Background Over 1000 mutations of the cystic fibrosis transmembrane conductance
regulator gene (CFTR) that cause cystic fibrosis have been identified. We examined the …

Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated
with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation …

Objective To test for an association between the apolipoprotein E (APOE) ϵ4 allele and
dementias with synucleinopathy. Design Genetic case-control association study. Setting …

Background—Familial combined hyperlipidemia (FCHL) and familial hypertriglyceridemia
(FHTG) are 2 of the most common familial forms of hyperlipidemia. There is a paucity of …

One of the most common challenges faced by health professionals is encouraging patients
to change their behavior to improve their health. This paper reports the development of a …

Endemic (Balkan) nephropathy is a chronic tubulointerstitial disease frequently
accompanied by urothelial cell carcinomas of the upper urinary tract. This disorder has …

Importance Cognitive impairment is a common and disabling problem in Parkinson disease
(PD) that is not well understood and is difficult to treat. Identification of genetic variants that …