Tm is defined as Temperature of melting or, more accurately, as temperature of
midtransition. This term is often used for nucleic acids (DNA and RNA, oligonucleotides and …

Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …

The telomeric G-rich single-stranded DNA can adopt in vitro an intramolecular quadruplex
structure, which has been shown to directly inhibit telomerase activity. The reactivation of …

Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50
histological subtypes,. The clinical presentation of patients with different subtypes is often …

Abstract We introduce the Microenvironment Cell Populations-counter (MCP-counter)
method, which allows the robust quantification of the absolute abundance of eight immune …

Oligodeoxynucleotides which include stretches of guanines form a well‐known tetrameric
structure. We show that the recording of reversible absorbance changes at 295 nm allows to …

Dendritic cell-derived exosomes (Dex) are small extracellular vesicles secreted by viable
dendritic cells. In the two phase-I trials that we conducted using the first generation of Dex …

We present the intramolecular G-quadruplex structure of human telomeric DNA in
physiologically relevant K+ solution. This G-quadruplex, whose (3+ 1) topology differs from …

High-throughput genomic analyses may improve outcomes in patients with advanced
cancers. MOSCATO 01 is a prospective clinical trial evaluating the clinical benefit of this …

The average evaporation heat-transfer coefficient for the interline region of an adsorption
controlled wetting film in which the disjoining pressure is approximated by P d=− A ̄ δ− 3 …