Approximately, 16 million strokes occur worldwide each year, causing 6 million deaths and
considerable disability, implying an enormous social, individual health, and economic …

Cell-based therapy has demonstrated safety and efficacy in experimental animal models of
stroke, as well as safety in stroke patients. However, various questions remain regarding the …

CDP-choline has been widespread used in humans for decades as a treatment for many
types of cognitive impairment. Despite this, its mechanism of action still remains unclear, but …

Introduction Stem cell therapy can promote good recovery from stroke. Several studies have
demonstrated that mesenchymal stem cells (MSC) are safe and effective. However, more …

Mesenchymal stem cells have previously been shown to mediate brain repair after stroke;
they secrete 50–100 nm complexes called extracellular vesicles (EVs), which could be …

Hematic administration of bone marrow-derived mesenchymal stem cells (MSCs) in acute
ischemic stroke may not only be an effective reparative treatment but also a brain protective …

Exosomes are gaining importance because they show great promise in therapeutic
applications for several diseases. Particularly in stroke, exosomes derived from …

Background Few studies have evaluated the possible beneficial effect of the administration
of stem cells in the early stages of stroke. Intravenous administration of allogeneic …

Background and Purpose—Translational research is beginning to reveal the importance of
trophic factors as a therapy for cellular brain repair. The purpose of this study was to analyze …

Extracellular vesicles (EVs) have emerged as important mediators of intercellular
communication and as possible therapeutic agents in inflammation-mediated demyelinating …