The Ussing chamber technique is a simple, but powerful technique to investigate ion
transport. Originally designed to study vectorial ion transport through the frog skin, it has …

In patients with cystic fibrosis, cystic fibrosis transmembrane conductance regulator (CFTR)
biomarkers, such as sweat chloride concentration and/or nasal potential difference, are used …

Background Metabolic syndrome and related metabolic disturbances represent a state of
low-grade inflammation, which accelerates insulin resistance, type 2 diabetes (T2D) and …

BACKGROUND: Patients irradiated for brain tumors often suffer from cerebral edema and
are usually treated with dexamethasone, which has various side effects. To investigate the …

Although it is generally recognized that cystic fibrosis transmembrane conductance regulator
(CFTR) contains a PSD-95/Disc-large/ZO-1 (PDZ)-binding motif at its COOH terminus, the …

The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl−
channel whose activity is controlled by cAMP-dependent protein kinase (PKA)-mediated …

Background: Dosage of T4 in central hypothyroidism is primarily guided by the free serum
T4 level (fT4). However, the optimum fT4 range is ill defined, and subtle hypothyroidism …

Personalized antibiotherapy ensures that the antibiotic concentration remains in the optimal
therapeutic window to maximize efficacy, minimize side effects, and avoid the emergence of …

Defective HCO3–and fluid secretion are hallmarks of the pathophysiology of the pancreas of
cystic fibrosis patients. Recently, impaired HCO3–secretion has been shown in most tissues …

CFTR function in patients with cystic fibrosis (CF) carrying the G551D-CFTR mutation was a
major breakthrough raising hope that causal drug therapy may become possible on a larger …