The prevalence of obesity has increased considerably in the last few decades.
Pathophysiological changes in obese patients lead to pharmacokinetic (PK) and …

Outpatient parenteral antimicrobial therapy (OPAT) with continuous infusion pumps is
postulated as a very promising solution to treat complicated infections, such as endocarditis …

Voriconazole is an antifungal metabolised by CYP2C19 enzyme, which can be inhibited by
proton‐pump inhibitors (PPIs). A prospective observational study was carried out to …

Background Voriconazole, a first‐line agent for the treatment of invasive fungal infections, is
mainly metabolized by cytochrome P450 (CYP) 2C19. A significant portion of patients fail to …

Objective Voriconazole is an antifungal agent used in the treatment of aspergillosis and
fluconazole-resistant Candida infections. Therapeutic drug monitoring (TDM) of …

Introduction Audits for monitoring the quality of antimicrobial prescribing are a main tool in
antimicrobial stewardship programs; however, interobserver reliability has not been …

Background The pharmacist is incorporated step by step to daily clinical activities at hospital.
However, there is still a lack of uniformity both among the tasks assumed and also the way of …

Background Some drugs can cause Syndrome of Inappropriate Antidiuretic Hormone
Secretion (SIADH). Tolvaptan is a new drug to treat SIADH. There is a lack of studies about …

Background Immunomodulatory drugs represent the best therapeutic option in first-line
treatment of relapsing-remitting multiple sclerosis (RRMS). This group includes glatiramer …

El trasplante hepático es un procedimiento de gran complejidad. A pesar de los continuos e
importantes avances en las técnicas quirúrgicas anestésicas y en los recursos …