Antidepressants are part of the pharmacological management of depressive and anxiety disorders in oncology. In a palliative situation, several properties can enhance their indications, such as hot flushes induced by hormone therapy and neuropathic pain. For frail patients in the palliative stage, pharmacological interactions, their possible side effects and the modalities of their prescription should always be taken into account. In this review, the different classes of antidepressants that can be used in palliative care are described. These classes are briefly compared in terms of efficacy and safety. Suggestions on the best choice according to other symptoms are proposed.
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