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European Study for Neonatal Excipient Exposure (ESNEE)
  1. Mark A Turner1,
  2. Thomas Storme2
  1. 1Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool Neonatal Unit, Liverpool Women's NHS Foundation Trust, Liverpool, UK
  2. 2Assistance Publique Hôpitaux de Paris, Hôpital Robert Debré, Service de Pharmacie, Paris, France
  1. Correspondence to Dr. Mark Turner, Neonatal Unit, Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, UK; mark.turner{at}liverpool.ac.uk

https://doi.org/10.1136/ejhpharm-2012-000065

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    Excipients are frequently used to facilitate the manufacture and storage of medicines. Pharmacological effects and adverse events can be attributed to excipients. Examples in adults include effects of excipients on taxane pharmacology. There is significant overlap between medicinal excipients and food additives. Safety assessments of excipients and food substances draw on laboratory science, toxicology and assessment of the clinical consequences of exposure. The application of these methods allows a reasonable assessment of excipient and food additive safety in adults.

    Children are different from adults, and neonates are different from children. Neonates (babies born prematurely or within 28 days of term …

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    Footnotes

    • Competing interests None.

    • Provenance and peer review Commissioned; not externally peer reviewed.