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DGI-042 Hypomagnesemia as a Possible Marker of Efficacy in Patients with Head and Neck Carcinoma in First-Line Treatment with Cetuximab
  1. J Ruiz1,
  2. JE Megías1,
  3. C Borrell1,
  4. P Marrero1,
  5. E López1,
  6. JL Poveda1
  1. 1Hospital Universitario La Fe, Pharmacy, Valencia, Spain


Background It has been reported that the determination of magnesium levels could be used as a surrogate marker of efficacy in chemotherapy regimens with cetuximab.

Purpose To investigate the hypomagnesemia caused by cetuximab as a predictor of efficacy and outcome in patients affected by head and neck cancer in first-line treatment.

Materials and Methods Retrospective observational study (Study period: November 2008–October 2012). We analysed patients with head and neck carcinoma treated with cetuximab in first-line treatment, who had magnesium determinations from the start of treatment until one month after the end of treatment with cetuximab. Patients with magnesium determinations were stratified into two groups: Patients who presented hypomagnesemia during the treatment (<1.7 mg/dL) and patients who didn’t present hypomagnesemia. The primary outcome was to compare remission rate, progression-free survival (PFS) and overall survival (OS) in the two groups. PFS and OS were both determined by the Kaplan-Meier product-limit method.

Results We collected a total of 14 patients (92.8% male). The median age at onset of treatment was 61 years (range: 21–86). Six patients developed hypomagnesemia during treatment. The most common diagnosis was carcinoma of the oral cavity (28.6%) followed by laryngeal carcinoma (21.4%). The group of patients who presented hypomagnesemia showed a higher remission rate (66.7% vs. 37.5% patients), OS [mean: 34.8 (18.8 to 50.9)) vs. 22.4 (95% CI: 11.9 to 32.9 months, p = 0.532] and PFS [34.5 months (18.11 to 50.9), vs. 19.7 (7.8–31.5) p = 0.456] in comparison with the group in which hypomagnesaemia was not detected.

Conclusions Despite the small number of patients studied, hypomagnesemia could be a marker of cetuximab efficacy in first-line treatment in patients with head and neck cancer. Magnesium levels should be determined routinely in patients treated with cetuximab.

No conflict of interest.

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