Background Body mass index (BMI) is a factor related to the disposition of aminoglycosides (AMG). Dosage is based on total body weight (TBW) or adjusted body weight (ABW) according to patients’ BMI.
Purpose To assess if the amikacin dosage prescribed to patients matches with the dosage based on BMI.
To calculate the optimal cut-off point of BMI that predicts a 10% discrepancy between dosage based on TBW or ABW.
Materials and Methods Retrospective study January 2003–December 2010 performed in a 450-bed tertiary hospital.
Dosage of 15 mg/TBW was considered except for patients with TBW > 30% over ideal body weight (IBW). That dose was calculated according to ABW: ABW(kg) = IBW + 0.4(TBW–IBW) as recommended.
Patients included: intravenous amikacin treatment of respiratory tract infections in an extended-interval dosing regimen with therapeutic drug monitoring of amikacin.
Patients excluded: <18 years, ClCr < 60 mL/min, sepsis, lack of data.
Data collected: demographics, TBW, height, BMI, renal function.
Amikacin levels: fluorescence polarisation immunoassay (TDX, Abbott Lab)
Pharmacokinetic analysis: Bayesian estimation compartmental model (PKS programme)
Statistical analysis: ROC curve.
Results 133 patients (79.70% men). Mean (±SD): age: 62.12 years (±15.48); TBW: 65.52kg (±13.43); height: 166.89 cm (±7.44); serum creatinine baseline: 0.68 (±0.19) and CrCl: 97.32 mL/min (±34.67).
Difference between TBW dose vs. ABW dose (mg)(%): BMI[<16]:16.45 vs. 16.45(0%); BMI[16–18.49]:16.57 vs. 16.57(0%); BMI[18.5–24.9]:15.28 vs. 15.61(2.2%); BMI[25–29.9]:12.70 vs. 14.30(11.2%); BMI[30–34.9]:11.56 vs. 14.34(19.3%); BMI[35–39.9] and [>40]: 1 patient.
A ROC curve was built to determine the best cut off point of BMI: 26 mg/m2
Difference between recommended dosage and prescribed dosage (mg): BMI[<16]: +1.45; BMI 16–18.49: +1.58; BMI[18.5–24.9]: +0.64; BMI[25–29.9]: −0.70; BMI[30–34.9]: −0.66; BMI[35–39.9] and [>40]: 1 patient.
Conclusions Considerable variation between the dosage of amikacin based on TBW and ABW was observed with a reduction of recommended dose in patients with BMI ≥ 25 kg/m2 and an overdose in patients with BMI < 24.9 kg/m2.
A reduction of 10% or more of the adjusted calculated dose of amikacin was observed in patients with BMI ≥ 26 kg/m2.
No conflict of interest.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.