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OHP-067 Prescription Profile Analysis of Proton Pump Inhibitors in a Tertiary Hospital
  1. A Díez Alcántara,
  2. V Saavedra Quirós,
  3. E Santiago Prieto,
  4. A Torralba Arranz
  1. Hospital Universitario Puerta de Hierro, Pharmacy, Madrid, Spain


Background In October 2011, selection criteria for proton pump inhibitors (PPIs) were published, recommending the use of omeprazole as a drug of choice because, at equipotent doses, it is the most cost-effective drug, compared to other PPIs.

Purpose To describe the prescription profile of PPIs for different consultants and in patients who are discharged from hospital.

Materials and Methods Information about the prescriptions for PPIs issued during 2011 was obtained from the pharmaceutical software. The data were analysed and classified according to therapeutic group, active principle, number of defined daily doses (DDDs), service and number of prescriptions. The percentage DDD of each active principle with respect to the PPI group as a whole was also investigated.

Results During 2011, 9.654 prescriptions were written. Gastroenterology was the Medical Service with the most prescriptions, followed by Internal Medicine and Otolaryngology. The percentage DDD of each PPI prescribed in each service, related to the whole of the PPIs was:

  • Gastroenterology: 26% omeprazole; 14% pantoprazole; 18% lansoprazole; 16% esomeprazole; 26% rabeprazole. Total, 2213 prescriptions.

  • Otolaryngology: 55% omeprazole; 22% pantoprazole; 2% lansoprazole; 7% esomeprazole; 14% rabeprazole. Total, 1074 prescriptions.

  • Internal Medicine: 82% omeprazole; 7% pantoprazole; 0,5% lansoprazole; 10% esomeprazole; 0,5% rabeprazole. Total, 619 prescriptions.

Conclusions Omeprazole is the PPI with the highest percentage of DDD prescribed, nevertheless prescriptions for it are on the low side (less than 30% in Gastroenterology and Otolaryngology, and less than 85% in Internal Medicine); this means that there is still a lot more room for improvement. The Service which made the best selection of IPPs was Internal Medicine, followed by Otolaryngology, and finally Gastroenterology.

Despite the low number of prescriptions made in hospital, compared to the ones prescribed in Primary Care, there is still a lot of work to be done to improve the selection of IPPs prescribed in hospital.

No conflict of interest.

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