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GRP-012 Adherence, Persistence and Financial Evaluation in the Treatment of Prostate Cancer
  1. P Sorice,
  2. F Santoleri,
  3. R Lasala,
  4. RC Rizzo,
  5. A Costantini
  1. General Hospital of Pescara, Hospital Pharmacy, Pescara, Italy


Background The success of home treatment is strongly influenced by patient adherence to treatment. Non-adherence to treatment represents not only an important issue for the patient, affecting both the clinical efficacy and safety of the drug treatment, but also has financial and social implications for the community.

Purpose This study evaluated the adherence to treatment, persistence, and the daily cost of treatment in patients with prostate cancer treated with gonadotropin-releasing hormone agonists, comparing leuprorelin 3.75–11.25, leuprorelin 7.5–22.5 and triptorelin.

Materials and Methods Adherence to treatment was measured as the ratio between the Received Daily Dose (RDD) and the Prescribed Daily Dose (PDD), using software developed for this purpose by hospital pharmacists. The RDD was calculated as the sum of the number of days between two consecutive drug refills, whilst the PDD was determined based on the treatment regimen as prescribed by the physician. The persistence was calculated as the sum of the number of days the patient had stayed on treatment.

The cost of daily treatment was calculated on the basis of the RDD.

Results 126 patients were enrolled in this study for triptorelin, 143 for leuprorelin 3.75–11.25 and 31 for leuprorelin 7.5–22.5. The adherence values for all drugs ranged between 0.95 and 1.10, showing good quality management of domiciled treatment. The analysis of persistence conducted over three years showed a decrease by 20% for leuprorelin 3.75–11.25, 25% for triptorelin and 50% for leuprorelin 7.5–22.5. The cost per RDD was €.2.15, €.2.24 and €.2.84 for leuprorelin 7.5–22.5, leuprorelin 3.75–11.25 and triptorelin respectively.

Conclusions The excellent adherence values showed that all the drugs studied have a good safety profile and easy administration. In fact, patients complied with the dosage and medication regimens as recommended by prescribers. The persistence values were overlapping. The cost per RDD for triptorelin was 23% higher than leuprorelin.

No conflict of interest.

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