Article Text

Download PDFPDF

GRP-163 Risk Management Measures to Prevent Physical-Chemical Incompatibilities During Continuous IV Infusion
  1. C Linguadoca1,
  2. S Parazza1,
  3. E Musi1,
  4. A Zanardi1,
  5. F Caliumi1,
  6. MV Antonini2,
  7. ML Caspani2
  1. 1Azienda Ospedaliero-Universitaria Parma, Servizio di Farmacia e Governo Clinico del Farmaco, Parma, Italy
  2. 2Azienda Ospedaliero-Universitaria Parma, I Servizio di Anestesia e Rianimazione, Parma, Italy


Background Patients in critical care (ICU) settings usually require multiple medicines administered as continuous IV infusions. As a reliable IV access is often unavailable, simultaneous administration through the same line is performed using a Y-site connector.

If any drug/drug or drug/solvent incompatibilities occur, physical-chemical reactions may occur at the Y-site expressed as clouding, colour variation, emulsion breaking. These reactions can give rise to clinically significant complications such as reduction of bioavailability and therapeutic effect, catheter obstruction, parenchymal deposits. The potential impact, in terms of increase of morbidity/mortality and prolonged hospitalisation, could be important.

Purpose To create a working tool to help health professionals make responsible and evidence-based decisions when administering several medicines to critical patients.

Materials and Methods A systematic search for stability/compatibility information for injectable drugs was performed (Trissel’s, Stabilis, King’s Guide to Parenteral Admixtures, Micromedex database, Martindale, Summary of Product Characteristics).

A literature review of data concerning compatibility for intravenous administration of 119 drugs and 4 diluents commonly used in anaesthesia and intensive care was undertaken.

Results 7488 drug/drug and drug/solvent compatibilities were analysed, showing: 44% compatibility, 12% physical and/or chemical incompatibility, 4.5% limited compatibility (depending on solvent, concentration, contact time, temperature). The data collected conflicted in 1.8% of references.

All data were summarised in a colour-code wall chart, which admits, circumscribes or denies the possibility of simultaneous infusion (green: compatible, red: incompatible, violet: limited data, yellow: conflicting data, white: no information). This working tool was shared with health staff and made available in the ward for a safe and quick search.

Conclusions The use of this visual working tool in ICUs and other units may reduce adverse events due to physical-chemical incompatibility of infused medicines, thus improving care quality and patient safety.

No conflict of interest.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.