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PP-024 The automated compounding of paclitaxel albumin as a sustainable alternative to the traditional compounding
  1. A Marinozzi1,
  2. C Bufarini1,
  3. S Guglielmi1,
  4. V Rosini2,
  5. D Paolucci2
  1. 1University Hospital of Ancona, Oncology Pharmacy, Ancona, Italy
  2. 2Loccioni, Humancare, Moie dDi Maiolati (AN), Italy


Background Paclitaxel albumin is indicated for the treatment of metastatic carcinoma of breast after failure of anthracycline therapy. It is notoriously a delicate drug to handle because it is a suspension with high tendency to foam. According to the information sheet, the drug reconstitution requires particularly attention during solvent injection. Furthermore, the vial needs to stand for 5 and 15 min, respectively before and after shaking, to reduce the foam. As a consequence, the therapy compounding appears laborious and demanding for technicians.

Purpose To automate the compounding of Abraxane with APOTECAchemo and analyse the related performances.

Materials and methods The manual procedure was deeply analysed to evaluate the feasibility to robotize the compounding of Abraxane. 10 preparations are compounded manually, according to the data sheet. Afterwards, 10 preparations of Abraxane were carried out with APOTECAchemo, following the standard procedure of the system. However, the vials were left to rest for 10 min after reconstitution, before going on with the compounding.

The preparations are analysed in terms of dosage accuracy and compounding time.

Results The preparations compounded manually showed an average dosage error of 1.5% and a compounding time of 30 min. The dosage accuracy of preparations done automatically was -0.5%. The total compounding time resulted in 22 min for preparation: 7 min for reconstitution of 2 vials, 10 min for vial standing and 5 min for compounding. The 10-minute rest time resulted enough to significantly reduce the foam.

Dosage accuracy of the automatic procedure resulted similar or better than the manual compounding. In contrast, the use of APOTECAchemo implied a notable reduction of compounding time of 26%.

Conclusions The automation of Abraxane preparation resulted feasible and sustainable. Because the dosage accuracy of APOTECAchemo is comparable with manual activity and compounding time is even shorter, the automatic compounding represents an easy and convenient alternative to the traditional practice.

No conflict of interest.

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