Article Text

Download PDFPDF
CP-115 Evolution of immunoglobulin prescriptions in a tertiary hospital
  1. C Pérez Diez,
  2. V Gimeno,
  3. MJ Agustín-Ferrández,
  4. O Pascual-Martínez,
  5. M Uriarte,
  6. I Larrodé
  1. Universitary Hospital Miguel Servet, Farmacia Hospitalaria, Zaragoza, Spain


Background Intravenous immunoglobulins (IVIG) are prepared in the sterile area of a Pharmacy Service (PS).

Purpose To analyse IVIG prescriptions before and after an update of the IVIG protocol.

Materials and methods Retrospective study to compare IVIG prescribed in period 1 (January 2012–March 2012) with those prescribed in period 2 (January 2013–March 2013). The update of protocol was approved in January 2013. IVIG indications were classified according to level of evidence and the ideal weight-adjusted dose was established for each indication. Type of IVIG prescribed, dose (g/kg/day), total dose, medical service and indication were recorded.

Results 122 and 88 patients were treated with IVIG in period 1 and 2 respectively (82.0% and 72.0% throughout each period). The hospital services that prescribed more IVIG were in both periods Haematology (74.0% in period 1 and 70.0% in period 2) and Neurology (15.0% and 18.0% respectively). The main indication for IVIG was common variable immunodeficiency (CVID) (26.0% and 35.0% in period 1 and 2 respectively), followed by secondary immunodeficiency type LLC (17.0% and 16.0% respectively for the two periods). Other indications were primary immune thrombocytopenia (ITP) (20.0%), chronic polyradiculoneuritis (7.0%) and Burton’s syndrome (7.0%) during period 1 and chronic polyradiculoneuritis (10.0%) and PTI (8.0%) during period 2. The use of IVIG declined by a total of 16.5% (92,154 euros). It has declined in Burton’s syndrome patients (80.2%); in ITP patients (67.3%) because IVIG was approved only for those with severe bleeding (WHO bleeding scale grade >2) and in CLL patients (20.4%), for whom the IVIG dose was adjusted according to clinical infectious to maintain the concentration of IVIG >600 mg/ml.

Conclusions Updating the IVIG protocol has enabled IVIG to be used more efficiently. There has been a saving in the treatment of ITP and the administration of IVIG for PTI, LLC and Burton’s syndrome has decreased.

No conflict of interest.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.