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Drug information and pharmacotherapy
DI-093 Predictors of non-adherence to highly active antiretroviral therapy in HIV-infected patients
  1. E Gómez Fernández1,
  2. R Jimenez Galan1,
  3. Y Borrego Izquierdo1,
  4. MR Cantudo Cuenca1,
  5. F Orantes Casado de Amezua2,
  6. M Robustillo Cortes1,
  7. E Calvo Cidoncha1,
  8. M Manzano Garcia1,
  9. C Haro Márquez1,
  10. R Morillo Verdugo1
  1. 1Hospital de Valme, Pharmacy Service, Seville, Spain
  2. 2Hospital Virgen de Las Nieves, Pharmacy Service, Granada, Spain

Abstract

Background Highly active antiretroviral therapy (HAART) has significantly reduced morbidity and mortality, transforming HIV into a chronic disease. The increase in life expectancy in these patients has led to a higher prevalence of comorbidities and use of concomitant medicines, which may limit adherence and therapeutic success.

Purpose To determine the prevalence of other chronic diseases in HIV-infected patients and to identify predictors of non-adherence to HAART.

Material and methods Single-centre retrospective study that included HIV-infected patients on HAART who attended pharmaceutical care at a pharmacy service from January to December 2013. The dependent variable was non-adherence to HAART (patients were considered non-adherent to HAART if the percentage of adherence through dispensing records was ≤90%). The independent variables were: sex, age, number of chronic diseases and concomitant medicines, and the presence of specific diseases (viral liver disease, dyslipidaemia, central nervous system disease, cardiovascular disease or hypertension).

Statistical analysis: to identify independent predictors of non-adherence, we performed a multivariate logistic regression analysis.

Results A total of 598 patients were analysed. 78.9% were men, mean age was 48 years (IQR: 42–52). The average number of comorbidities per patient was 1.6 ± 1.4. 31.3% of patients had viral liver disease, 17.9% dyslipidaemia, 15.6% central nervous system disease and 14.4% cardiovascular disease or hypertension. The average number of concurrent drugs per patient was 1.9 ± 2.7. 85.3% of patients were adherent to HAART. In the multivariate analysis, presence of viral liver disease was the only variable significantly associated with non-adherence to HAART (OR: 1.81); p = 0.02). The number of chronic diseases and concurrent drugs was not associated with non-adherence.

Conclusion The prevalence of other chronic diseases in HIV-infected patients was high. The presence of viral liver disease was identified as a predictor of non-adherence in HIV-patients in this study.

Reference

  1. Gleason LJ, et al. Polypharmacy in the HIV-infected older adult population. Clin Interv Aging 2013;8:749–63

ReferenceNo conflict of interest.

https://doi.org/10.1136/ejhpharm-2015-000639.267

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