Background Defined daily dose per 100 occupied bed-days (DDD/100 OBD) is a quality indicator used for controlling antimicrobial use in the hospital setting. Information is lacking about the impact of clinical trials (CT) focused on infectious diseases in the overall consumption of antimicrobials.

Purpose To assess the impact of the antibiotic consumption (AC) from CT performed in Infectious Diseases (ID), General Surgery (GS) and Intensive Care Unit (ICU) departments on the AC of these settings.

Material and methods Retrospective study performed in an university hospital from June 2012 to April 2014. Data collected: Nº CT with antibiotics in ID, GS and ICU wards; number of patients for each CT. Overall DDD/100 OBD of AC from the hospital and CTs were calculated and compared for each department by means of the standard WHO formula.

DDD/100 OBD for investigational drugs were estimated from the available antibiotics used as comparators.

Results Nº CT:5. ID:3, GS:1 and ICU:1. Nº patients: ID:18, GS:6 and ICU:1.

Conclusion

• DDD/100 OBD of investigational antibiotics from CT should be added to the overall hospital AC data to avoid an underestimation of the antibiotic selection pressure mainly from ceftazidime consumption.

• This indicator should be also used to calculate more accurately the AC in those departments that conduct a high number of CT like the ID.

• Further studies should be designed to know which actions should be triggered from these results.

References and/or Acknowledgements

1. WHO Collaborating Centre for Drug Statistics Methodology. ATC/DDD Index 2014. http://www.whocc.no/atc_ddd_index/

References and/or AcknowledgementsNo conflict of interest.