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Stability of daptomycin in peritoneal dialysis solutions packaged in dual-compartment infusion bags
  1. Sagar Ramdas1,
  2. Farzana Yousaf1,
  3. Madhur D Shastri1,
  4. Troy Wanandy1,2,
  5. Syed T R Zaidi1,2,
  6. Manish Khandagale3,
  7. Matthew Jose4,5,
  8. Rahul P Patel1
  1. 1Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
  2. 2Pharmacy Department, Royal Hobart Hospital, Hobart, Tasmania, Australia
  3. 3Division of Chemistry, Faculty of Science, Engineering and Technology, Australian Centre for Research on Separation Science, University of Tasmania, Hobart, Tasmania, Australia
  4. 4Division of Medicine, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
  5. 5Nephrology Department, Royal Hobart Hospital, Hobart, Tasmania, Australia
  1. Correspondence to Dr Rahul P Patel, Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania 7005, Australia; Rahul.Patel{at}utas.edu.au

Abstract

Background Intraperitoneal daptomycin is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by vancomycin-resistant bacteria. This study investigated the stability of daptomycin in a pH-neutral PD solution.

Methods Reconstituted solution of daptomycin was added to a total of nine PD bags to obtain a concentration of 20 mg/L and stored at 1 of 3 different temperatures: 4 or 25°C for up to 168 h or 37°C for up to 48 h. Stabilities were determined by visual inspection, pH measurement and high-performance liquid chromatography.

Results Daptomycin retained more than 90% of its initial concentration for 120, 72 and 12 h at 4°C, 25°C and 37°C, respectively. No physical precipitation or pH change was observed during the study.

Conclusions Daptomycin in a pH-neutral PD solution is physically and chemically stable for 120 and 12 h at 4°C and 37°C, respectively.

https://doi.org/10.1136/ejhpharm-2015-000651

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