Article Text

Download PDFPDF
Cross-sectional analysis of retrospective case series of hospitalisations for gastropathy caused by non-steroidal anti-inflammatory treatment: risk factors and gastroprotection use
  1. José Luis Marco Garbayo1,
  2. Manuel Koninckx Cañada1,
  3. Isabel Pérez Castelló1,
  4. María Teresa Faus Soler1,
  5. Rosa Fuster Torres2,
  6. Mar Moncho Escrivà1
  1. 1 Department of Hospital Pharmacy, Francesc de Borja Hospital of Gandia, Valencia, Spain
  2. 2 Department of Clinical Documentation and Admission, Francesc de Borja Hospital of Gandia, Valencia, Spain
  1. Correspondence to Dr Manuel Koninckx Cañada, Department of Hospital Pharmacy, Francesc de Borja Hospital of Gandia, Av. de la Medicina, 6, Gandia, Valencia 46701, Spain; koninckx1{at}


Objectives To analyse the risk factors of gastropathy caused by using non-steroidal anti-inflammatory drugs (NSAIDs) in detected hospital admissions and to analyse the use of gastroprotective treatment concerning these risk factors.

Methods A retrospective observational study was carried out in the framework of an integral risk management plan of drugs and proactive pharmacovigilance of hospital admissions for NSAID-induced gastropathy occurring between 2011 and 2015. Cases were identified after reviewing the ICD-9 codes related to NSAID-induced gastropathy in hospital discharge reports. Various biometric, clinical and pharmacotherapeutic variables of each patient were registered. The gastroprotective criteria set out in the therapeutic decision algorithm of the Valencian Health System were followed.

Results 62 hospital admissions for NSAID-induced gastropathy were detected. The mean length of stay was 5.3±3.8 days. Ibuprofen was the most prevalent NSAID (28 cases, 45.2%). 24 cases (38.7%) took NSAIDs in the week before hospitalisation. The prevalence of relevant risk factors for gastropathy were age >60 years (37 cases, 59.7%), concomitant medication (24 cases, 38.7%) and a history of peptic ulcer (9 cases, 14.5%). 41 patients (66.1%) met gastroprotective major criteria, 18 of whom (43.9%) were using a proton pump inhibitor following a prevention plan.

Conclusions In this study all relevant gastroprotective criteria were associated with the use of gastroprotection in detected hospital admissions for NSAID-induced gastropathy. However, a lack of gastroprotection was observed in a large number of detected cases with the criteria to use it. The feedback of our results to health area agents can serve to reinforce the safe use of NSAIDs.

  • upper gastrointestinal bleeding
  • nonsteroidal anti-inflammatory agents
  • acetylsalicylic acid
  • hospitalization
  • risk factors
  • anti-ulcer agents
  • pharmacovigilance
  • safety
  • metamizole

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.