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CP-027 Efficacy of compounding topical tacrolimus for subepithelial corneal infiltrates treatment
  1. S Berisa1,
  2. AC Riestra1,
  3. C Lisa2,
  4. JF Alfonso2
  1. 1Instituto Oftalmológico Fernandez Vega, Hospital Pharmacy Service, Oviedo, Spain
  2. 2Instituto Oftalmológico Fernandez Vega, Ophthalmology, Oviedo, Spain


Background Epidemic keratoconjunctivitis is a highly contagious infection that mainly involves the surface of the eye. Keratitis may appear approximately 10 days after the onset of follicular conjunctivitis, with the formation of subepithelial corneal infiltrates (SEIs), usually bilaterally and asymmetric. SEIs have the potential to cause significant ocular morbidity, with reduced vision, photophobia, glare, halos and foreign body sensation, and can persist for months or years after the initial infection. Tacrolimus has demonstrated effectiveness in this ocular pathology in some studies.

Purpose Our aim was to determine the efficacy of compounding topical tacrolimus treatments for SEIs after adenovirus keratoconjunctivitis.

Material and methods This retrospective study included patients who were treated with tacrolimus 0.03% eye drops twice daily or tacrolimus 0.2% ointment once daily for SEIs. The parameters measured were visual acuity before and after treatment, measured by LogMAR, intraocular pressure before, during and at the end of treatment, measured by Perkin’s tonometer, and other treatments before tacrolimus and the result of SEIs after treatment. The data were analysed using IBM Microsoft SPSS Statistics V.22.0.

Results We analysed 63 patients (99 eyes); 57.1% were affected bilaterally. Mean age was 46.85 years (SD 14.93). 26 patients (41.3%) were treated with tacrolimus 0.02% ointment and 37 patients (58.7%) with tacrolimus 0.03% eye drops. Mean duration of treatment was 105 days (range 55–199) and mean follow-up was 112.5 days (57.25–426.75). In 56.56% of eyes there was a decrease in SEIs, and in 19.19% they disappeared. We had data for visual acuity (VA) for 32 eyes. We observed an increase in VA in 17 eyes (53.1%), with a mean value of 0.331 (range 0.1–0.7). In 3 eyes (9.37%), VA decreased (0.1); there was no differences for 12 eyes (37.5%). Mean intraocular pressure was reduced in the right eyes based on media data.

Conclusion Topical tacrolimus eye drops and ointment, which?are compounded in the pharmacy service, seems to be an effective treatment for SEIs after adenovirus keratoconjunctivitis.

References and/or acknowledgements Ghanem RC, Vargas JF, Ghanem VC. Tacrolimus for the treatment of subepithelial infiltrates resistant to topical steroids after adenoviral keratoconjunctivitis. Cornea2014;33:1210–13.

No conflict of interest

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