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CP-201 Polypharmacy and potentially inappropriate medications in geriatric outpatients
  1. WO Chu1,
  2. FS Cheng2,
  3. LC Chen1,
  4. CL Lee3,
  5. LY Huang4,
  6. WJ Sun5
  1. 1Taipei City Hospital, Department of Pharmacy, Taipei, Taiwan ROC
  2. 2Taipei City Hospital, Department of Education and Research, Taipei, Taiwan ROC
  3. 3Taipei City Hospital, Department of Pharmacy Zhongxing Branch, Taipei, Taiwan ROC
  4. 4Taipei City Hospital, Department of Community Medicine, Taipei, Taiwan ROC
  5. 5Taipei City Hospital, Centre of R/D in Community Based Palliative Care, Taipei, Taiwan ROC


Background The growing ageing population and increasing prevalence of chronic diseases requires the simultaneous use of drugs, leading to issues of polypharmacy and potential interactions and inappropriate use.

Purpose To evaluate the prevalence of polypharmacy and potentially inappropriate medication (PIM) use and the association between these and number of prescribing medications and number of physician office visits in older adults.

Material and methods Using the Healthcare Information System (HIS) in Taipei City Hospital, we enrolled 159 elderly adults (aged ≥80 years) who had been prescribed 10 or more chronic medications (drugs prescribed for ≥28 days) and visited three or more different physician offices from 1 April 2016 to 30 June 2016. The EU(7)-PIM list was used to determine the potential inappropriateness of prescribed medications. Data were analysed using multiple regression analysis by the SPSS 22. A value of p<0.05 was considered statistically significant.

Results We enrolled 159 patients in our study where the ratio of men:women was 89:70. Mean (SD) age of our patients was 85.8 (10.2) years. The mean rate of prescribing medications was 14.1 (2.7) (maximum=19) orders per day, and number of physician office visits was 3.5 (0.5) (maximum=6). In the study, PIM use was common (94.5%) in geriatric outpatients and the number of PIM was 2.9 (0.5) (maximum=8). The most commonly prescribed PIM were sennoside (13.1%), theophylline (8.0%), piracetam (7.7%) and PPI (>8 weeks) (6.0%). In multiple regression analysis, PIM use was significantly associated with number of prescribing medications (p<0.001) and number of physician office visits in older adults (p=0.028).

Conclusion Of the 159 elderly persons in the study population, 150 (94.5%) received at least one PIM. Maybe we will establish computerised warning system and embed this into the HIS to decrease the medication number and PIM. The mainstay for preventing and managing polypharmacy remains heightened awareness of patients at risk. Pharmacovigilance is required by the patient, physician and pharmacist in thoroughly reviewing and reconciling the patient’s medication regimen at every opportunity.

References and/or acknowledgements We thank the Centre for Public Health, Department of Education and Research, Taipei City Hospital, Taiwan for their valuable contributions in data management and statistical analysis.

No conflict of interest

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