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Individualised antimicrobial dosing in critically ill patients undergoing continuous renal replacement therapy: focus on total drug clearance
  1. Jesus Ruiz1,
  2. Cassandra Favieres2,
  3. Maria Jesús Broch3,
  4. Esther Villarreal1,
  5. Monica Gordon3,
  6. Adrián Quinzá3,
  7. Álvaro Castellanos Ortega3,
  8. Paula Ramirez3
  1. 1Intensive Care Unit, Instituto de Investigación Sanitaria La Fe, Hospital Universitario y Politécnico La Fe, Valencia, Spain
  2. 2Pharmacy Depatment, Hospital Universitario y Politécnico La Fe, Valencia, Spain
  3. 3Intensive Care Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain
  1. Correspondence to Dr Paula Ramirez, Unidad de Cuidados Intensivos, Hospital Universitario y Politecnico La Fe, Avenida Fernando Abril Martorell n°106, Valencia 46026, Spain; ruisz_jesram{at}


Background Continuous renal replacement therapy (CRRT) is common practice in critical care patients with acute renal failure.

Objectives To evaluate the adequacy of antimicrobial doses calculated based on the total drug clearance and dose recommended by different guides in critically ill patients undergoing CRRT.

Methods Retrospective observational study. Patients admitted to a critical care unit during May 2014 to May 2016 and subjected to CRRT were included. The recommended dose was established as the product of the usual dose of the drug by total drug clearance.

Results 177 antimicrobial agents, used in 64 patients were analysed; 45 (25.4%) antimicrobials were given in an insufficient dose (<20%) according to the theoretical calculation. Following the recommendations in the revised guidelines, between 10% and 20% of antimicrobials were given in insufficient doses. A higher success rate of treatment in those patients not receiving a low drug dosage was seen (35.2% vs 24.0%).

Conclusions There is a great disparity between the antimicrobial dose prescribed, recommended and calculated based on drug clearance in critically ill patients undergoing CRRT.

  • Infection
  • hemofiltration
  • bacteremia
  • antibiotics

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